Nanosomes are vesicles based on phospholipids (at least PC80) as emulsifier.
10% each of natural DL-alpha-tocopherol were encapsulated in Lipo-Tops or nanosomes.
The effect of a solution containing pure vitamin E was set to 100%.
By encapsulating tocopherol into nanosomes, the antioxidative potential was increased to 350% in the viable skin.
The free radical scavening effects of vitamin E in the skin could be again boosted more than 2-times by the application of Lipo-Tops Tocopherol.
The anti-oxidative effect of Lipo-Tops Tocopherol will last for much longer time compared to the other applications (shown in the figure).
Determination of the skin penetration depth of a lipophilic fluoroscence dye (Dil) encapsulated in different carrier systems by confocal laser scan miscroscopy
1,1-Diocytadecyl-3,3,3,3-tetramethylindocarbocyanine perchlorate (Dil) [lipophil, moleculae weight = 934 Dalton]
The encapsulated fluorescence dye was applied onto the skin (ex vivo).
12 hours after application the Penetration of DiI (red model substance) was determined by confocal laser scan microscopy.
Sopharcos Dermal Drug Delivery
Dr. Gabriele Blume
Im Schloss 7
36396 Steinau an der Strasse / Germany
PHONE: +49(0) 66 63 – 91 90 99
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