Hydro-Tops Facts & Graphics

Hydro-Tops (multiple nanoemulsion) have significantly better properties than conventional flexible liposomes.

Hydro-Tops exhibit higher encapsulation efficiency of hydrophilic and poorly soluble active ingredients compared to liposomes

Hydro-Tops are penetrating faster and deeper into the skin in contrast to liposomes.

The stability of many active ingredients is significantly increased by the encapsulation into Hydro-Tops.

In contrast to liposomes, Hydro Tops are released out of aqueous bacterial nanocellulose (face masks, wound dressings) and therefore the active ingredients are able to can reach the target sides in skin

In contrast to liposomes, Hydro-Tops can also transport encapsulated components into the skin by very lipophilic formulations such as a lamellar cream.

2% each of epigallocatechin gallate (EGCG = extracted active ingredient from green tea) were encapsulated in Hydro Tops or liposomes.

The effect of a solution containing pure EGCG (control) was set to 100%.

By encapsulating EGCG into liposomes, the antioxidative potential was increased to 290% in the viable skin.

The free radical scavening effects of EGCG in the skin could be again boosted more than 2-times by the application of Hydro-Tops GTE (10% lipid).

Even to get nanosized Hydro-Tops the amount of emulsifier can be increased up to 25% due to the viscosity. In contrast to get small liposomes a maximun of 10% lecithin can be used. These differences in the vesicle compositions lead to an increase in the encapsulation efficiency of active ingredients and also in the kinetics of the penetration behavior.

The anti-oxidative effect of Hydro-Tops GTE will last for much longer time compared to the other applications (shown in the figure). Also applying Hydro-Tops with 20% of emulsifier (higher number of vesicles) the maximum of the anti-oxidative capacity is not reached within a period of 20 minutes.