Hydro-Tops in general

Challenge
– Water-soluble active ingredients are not able to reach the deeper skin layers or at all only slightly due to the skin barrier properties (protection against dehydration).

– Active substances with high molecular weights, such as proteins, are too big to pass the stratum corneum and to reach the viable skin area. Therefore collagen or hyaluronic acid cannot build up an effective depot in the dermis.

– Poorly soluble active substances cannot be dissolved in effective amounts in the formulation and therefore do not end up at their target sides.
Solution: Hydro-Tops:
– Multiple W/O/W nanoemulsion with unique properties

– Size 80 – 200 nm, homogeneous particle size

– Fast penetration into the skin and hair follicles

– Based on only one edible sunflower emulsifier

– Inner hydrophilic encapsulated substances are stabilized and protected by the surrounding oil phase

Advantages

Active ingredients effectively reach the deeper and viable skin layers
Partly only by the encapsulation of the active ingredients into the nanovesicles
Higher encapsulation efficiency and better penetration properties compared to conventional flexible liposomes
Cost saving by reducing the used concentration of active ingredients with equal biological effects or an increase in activity at the same cost
Stabilization of active ingredients
The skin-friendly carrier system allows long-term applications compared to formulations with high amounts of penetration enhancers
Incorporation of the nanoemulsions simply at the end of the production of the final formulations

Facts & Graphics

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